Dr. James Guest MD, Ph.D. is a Professor of Neurological Surgery at the Miami Project to Cure Paralysis in Miami, Florida. He obtained his MD degree from the University of Alberta in 1988 and completed neurosurgical residency training in Vancouver in 1998. He was certified by the Royal College of Surgeons of Canada and the American Board of Neurological Surgeons. During residency, he obtained a Ph.D. in Neuroscience at the University of Miami studying cell transplantation after spinal cord injury (SCI). In Vancouver, during the last years of residency, he collaborated with the nascent ICORD. He then moved to the Barrow Neurological Institute in Phoenix, Arizona for fellowship training in spinal surgery and research training in the primate motor system. He then returned to the University of Miami. Dr. Guest has a strong interest in translational research and clinical trials in SCI. He has received funding from Spinal Research, the DOD, the NIH, and the Craig Nielsen foundation. Together with colleagues, he translated autologous Schwann cell transplantation for SCI into human subjects through two sequential clinical trials. For these trials, his team also conducted neurophysiological studies. He is the PI in Miami for the North American Clinical Trials Network Registry and the RISCIS study. He is an AO Spine knowledge forum member and served on the California Institute for Regenerative Medicine grants working group for the past 4 years. He has conducted studies in large animal models including cell transplantation, the use of biomaterials and pioneered delivery methods that have been patented. Current work is in neuromodulation using deep brain stimulation of the mesencephalic locomotor region tested in in combination with epidural stimulation after SCI. The other main lab focus is the study of multi-organ blood flow after SCI. He is collaborating with researchers from the Bronx VA, Kessler Rehabilitation, and the University of Louisville to assess alterations in blood flow underlying normalization of blood pressure in high-level cervical injury subjects during epidural stimulation.