I have been investigating the impact of Spinal Cord Injury (SCI) on autonomic regulation of the cardiovascular system and have published over 60 peer-reviewed manuscripts describing the impact of autonomic nervous system (ANS) impairment on organ system function in persons with chronic SCI. Recently the focus of my investigatory work has been to describe the impact of ANS impairment on blood pressure regulation and the secondary consequences of hypotension and orthostatic hypotension on cognitive dysfunction and quality of life in persons with SCI. We were one of the first laboratories to document deficits in memory and information processing in hypotensive individuals with SCI compared to a normotensive SCI cohort, and believe that these deficits may stem, in part, from dysregulation of cerebral blood flow. Subsequent funding from the New Jersey Commission for Spinal Cord Research, the Veterans Affairs Rehabilitation & Development Service and the Craig H. Neilsen Foundation has supported our continued exploration to describe associations between blood pressure dysregulation, cerebral blood flow and cognitive performance in individuals with SCI.